Journal article

DURING HIV-1 INFECTION MOST BLOOD DENDRITIC CELLS ARE NOT PRODUCTIVELY INFECTED AND CAN INDUCE ALLOGENEIC CD4 T-CELLS CLONAL EXPANSION

PU CAMERON, U FORSUM, H TEPPLER, A GRANELLIPIPERNO, RM STEINMAN

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | WILEY | Published : 1992

Abstract

We have considered the possibility that antigen-presenting cells of the dendritic cell lineage may be infected in vivo and spread HIV-1 at the time dendritic cells initiate the clonal expansion of antigen-specific T cells. Dendritic cells were isolated from 25 HIV-1-infected subjects (CDC stages II-IV). Fewer dendritic cells were recovered from most infected subjects. Reduced numbers of total non-T cells were also found in these patients, so that preferential loss of dendritic cells did not occur. Dendritic cell function was assessed by stimulatory capacity for allogeneic CD4+ T cells in the mixed leucocyte reaction (MLR). Potent MLR stimulator activity was retained in the dendritic cell-enr..

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University of Melbourne Researchers