Journal article

SUSCEPTIBILITY OF DENDRITIC CELLS TO HIV-1 INFECTION IN-VITRO

PU CAMERON, MG LOWE, SM CROWE, U ODOHERTY, M POPE, S GEZELTER, RM STEINMAN

JOURNAL OF LEUKOCYTE BIOLOGY | FEDERATION AMER SOC EXP BIOL | Published : 1994

Abstract

We review recent work on the extent of HIV-1 infection of dendritic cells (DCs) and the consequences of exposure to virus. The reported levels of infection of DCs from blood have varied from "explosive" to "undetectable." The only study that used sorted DCs demonstrated little if any infectability, which may not be surprising given the very low levels of CD4 on the populations that were studied. HIV-1-pulsed, highly purified DCs function as potent antigen-presenting cells during the mixed leukocyte reaction and responses to superantigens. At the same time that the HIV-1-pulsed DCs stimulate CD4+ T cells in DC-T clusters, the virus is transferred to the responding lymphocytes and a vigorous p..

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University of Melbourne Researchers