Journal article
The Physiology and Pathophysiology of Gastroesophageal Reflux in Patients with Laparoscopic Adjustable Gastric Band
RY Chen, PR Burton, GJ Ooi, C Laurie, AI Smith, G Crosthwaite, PE O’Brien, G Hebbard, PD Nottle, WA Brown
Obesity Surgery | SPRINGER | Published : 2017
Abstract
Introduction: The effect of the laparoscopic adjustable gastric band (LAGB) on esophageal acid exposure and reflux is poorly understood. Optimal technique and normative values for acid exposure have not been established in this group. Methods: High-resolution manometry (HRM) and 24-h ambulatory esophageal pH monitoring were performed in three groups: asymptomatic LAGB, symptomatic LAGB, and pre-operative reflux patients. This technique utilized intraluminal pressure signatures during HRM to guide accurate pH sensor placement. Results: The LAGB groups were well matched: age 48 vs 51 years (p = 0.249), weight loss 27.3 vs 26.7 kg (p = 0.911). The symptomatic group had a larger gastric pouch (5..
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Funding Acknowledgements
Mr. Burton, Dr. Ooi, Mr. Chen, Ms. Laurie, Prof O'Brien and Prof Brown report being affiliated with the Centre for Obesity Research and Education. The Centre has received funding for research purposes from Allergan and Apollo Endosurgery, the manufacturers of the LapBand (TM). The grant is not tied to any specific research project, and neither Allergan nor Apollo Endosurgery had any control of the protocol, analysis and reporting of any studies. CORE also receives a grant from Applied Medical towards educational programs.Prof Brown reports financial support for a bariatric surgery registry from the Commonwealth of Australia, Apollo Endosurgery, Covidien, Johnson and Johnson, Gore and Applied Medical. She has also received a speaker's honorarium from Merck Sharpe and Dohme and a speaker's honorarium and fees from participation in a scientific advisory board from Novo Nordisk. The Bariatric Registry and the honorariums are outside of the submitted work.Dr. Ooi reports scholarships from the National Health and Medical Research Council and the Royal Australasian College of Surgeons.