Journal article

De-warping of images and improved eye tracking for the scanning laser ophthalmoscope

Phillip Bedggood, Andrew Metha

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2017

Abstract

A limitation of scanning laser ophthalmoscopy (SLO) is that eye movements during the capture of each frame distort the retinal image. Various sophisticated strategies have been devised to ensure that each acquired frame can be mapped quickly and accurately onto a chosen reference frame, but such methods are blind to distortions in the reference frame itself. Here we explore a method to address this limitation in software, and demonstrate its accuracy. We used high-speed (200 fps), high-resolution (~1 μm), flood-based imaging of the human retina with adaptive optics to obtain "ground truth" information on the retinal image and motion of the eye. This information was used to simulate SLO video..

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Grants

Awarded by Australian Research Council (ARC) Discovery Early Career Researcher Award


Awarded by ARC Discovery Project Grant


Funding Acknowledgements

This work received financial support from an Australian Research Council (ARC) Discovery Early Career Researcher Award (DE120101931), an ARC Discovery Project Grant (DP0984649), a benevolent bequest from the A.E. Rowden White Foundation, and seed-grants from the Melbourne Neuroscience Institute The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.This work received financial support from an Australian Research Council (ARC) Discovery Early Career Researcher Award (DE120101931), an ARC Discovery Project Grant (DP09846 49), a benevolent bequest from the A.E. Rowden White Foundation, and seed-grants from the Melbourne Neuroscience Institute (MNI @ the University of Melbourne). The problem of distortion in the reference frame, and possible avenues to correct for it, was brought to our attention through insightful conversations with Alfredo Dubra, to whom we are grateful.