Journal article
Effect of Combination Antiretroviral Therapy on HIV-1-specific Antibody-Dependent Cellular Cytotoxicity Responses in Subtype B- and Subtype C-Infected Cohorts
V Madhavi, A Kulkarni, A Shete, WS Lee, MR McLean, AB Kristensen, M Ghate, BD Wines, PM Hogarth, MS Parsons, A Kelleher, DA Cooper, J Amin, S Emery, M Thakar, SJ Kent
Journal of Acquired Immune Deficiency Syndromes | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
Background: There is growing interest in immune therapies to clear the latent HIV-1 after combination antiretroviral therapy (cART). There is limited information on the effect of cART on antibody-dependent cellular cytotoxicity (ADCC), and no studies have directly compared ADCC in HIV-1 subtype B- and subtype C-infected subjects. The effect of improving immunocompetence on ADCC to influenza also remains unexplored. Methods: The effect of cART on HIV-1- and influenza-specific ADCC was analyzed in 2 cohorts (39 subtype B- and 47 subtype C-infected subjects) before and after 2 years of cART. ADCC analyses included an enzyme-linked immunosorbent assay-based dimeric recombinant soluble (rs) FcγRI..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
Authors thank all the study subjects who donated blood samples for this study and Dr Rob Center, Burnet Institute, Australia, for kindly providing the HIV-1<INF>AD8</INF> Env protein. The authors also acknowledge the NIH-sponsored HIV Prevention Trials Network for the use of some of the stored samples and corresponding data included in this study.