Journal article
Biocompatible anti-microbial coatings for urinary catheters
VC Thompson, PJ Adamson, J Dilag, DB Uswatte Uswatte Liyanage, K Srikantharajah, A Blok, AV Ellis, DL Gordon, I Köper
Rsc Advances | ROYAL SOC CHEMISTRY | Published : 2016
DOI: 10.1039/c6ra07678e
Open access
Abstract
Using a simple dip-coating mechanism, urinary catheters have been coated with poly(2-methacryloyloxyethyl)trimethylammonium chloride (pMTAC) using activator regenerated by electron transfer (ARGET)-atom transfer radical polymerization (ATRP). A polydopamine-2-bromoisobutyryl bromide (pDA-BiBBr) initiator was initially grafted to the catheter surface to initiate polymerization resulting in a pDA-g-pMTAC coating. The pDA-g-pMTAC-coated catheters showed a significant reduction in bacterial adhesion, with respect to uncoated silicone catheters, as determined by analyzing microbiological assays as well as scanning electron microscopy images. At the same time, no evidence for cytotoxicity was obse..
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Funding Acknowledgements
Flinders Analytical is acknowledged for support of the ICP-MS experiments. Partial funding was provided by the Repat Foundation, Flinders University and the Flinders Centre for Nanoscale Science and Technology. Julie Calvert is acknowledged for TC cell maintenance.