Creatine biosynthesis and transport by the term human placenta
Stacey J Ellery, Paul A Della Gatta, Clinton R Bruce, Greg M Kowalski, Miranda Davies-Tuck, Joanne C Mockler, Padma Murthi, David W Walker, Rod J Snow, Hayley Dickinson
PLACENTA | W B SAUNDERS CO LTD | Published : 2017
INTRODUCTION: Creatine is an amino acid derivative that is involved in preserving ATP homeostasis. Previous studies suggest an important role for the creatine kinase circuit for placental ATP turnover. Creatine is obtained from both the diet and endogenous synthesis, usually along the renal-hepatic axis. However, some tissues with a high-energy demand have an inherent capacity to synthesise creatine. In this study, we determined if the term human placenta has the enzymatic machinary to synthesise creatine. METHODS: Eleven placentae were collected following elective term caesarean section. Samples from the 4 quadrants of each placenta were either fixed in formalin or frozen. qPCR was used to ..View full abstract
Awarded by Cerebral Palsy Alliance
Awarded by NHMRC
S.E. is funded by a career development fellowship from Cerebral Palsy Alliance to H.D (CDG0914); M.D.T is an NHMRC Early Career Fellow; H.D. is an NHMRC Career Development Fellow. A grant from the NHMRC to H.D., D.W. and R.S. (APP1047504) and the Victorian Government Infrastructure Support Fund to the Hudson Institute of Medical Research supported this work.