Journal article
Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits
F Grassmann, C Kiel, ME Zimmermann, M Gorski, V Grassmann, K Stark, IM Heid, BHF Weber, LG Fritsche, W Igl, JNC Bailey, S Sengupta, JL Bragg-Gresham, KP Burdon, SJ Hebbring, C Wen, IK Kim, D Cho, D Zack, E Souied Show all
Genome Medicine | BMC | Published : 2017
Open access
Abstract
Background: Age-related macular degeneration (AMD) is a common condition of vision loss with disease development strongly influenced by environmental and genetic factors. Recently, 34 loci were associated with AMD at genome-wide significance. So far, little is known about a genetic overlap between AMD and other complex diseases or disease-relevant traits. Methods: For each of 60 complex diseases/traits with publicly available genome-wide significant association data, the lead genetic variant per independent locus was extracted and a genetic score was calculated for each disease/trait as the weighted sum of risk alleles. The association with AMD was estimated based on 16,144 AMD cases and 17,..
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Awarded by Alcon Research Institute
Funding Acknowledgements
This study was supported in parts by the Deutsche Forschungsgemeinschaft (WE 1259/19-1 and WE 1259/19-2 to BHFW), the Alcon Research Institute (to BHFW), and by grants from the German Federal Ministry of Education and Research (BMBF 01ER1206 and 01ER1507 to IMH). Genotyping was conducted as part of the IAMDGC exome-chip project supported by CIDR (contract number HHSN268201200008I) and funded by EY022310 (to Jonathan L. Haines, Case Western Reserve University, Cleveland) and 1X01HG006934-01 (to Goncalo R. Abecasis, University of Michigan, Department of Biostatistics). The funding bodies had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.