Journal article
Association between PTGS1 polymorphisms and functional outcomes in Chinese patients with stroke during aspirin therapy: Interaction with smoking
H Cai, B Cai, L Sun, H Zhang, S Zhou, L Cao, H Guo, W Sun, B Yan, SM Davis, Z Zhang, X Liu
Journal of the Neurological Sciences | ELSEVIER SCIENCE BV | Published : 2017
Abstract
Purpose Prostaglandin-Endoperoxide Synthase 1 (PTGS1) and smoking may play important roles in aspirin nonresponsiveness, but the effect of their interaction on stroke outcomes remains largely unknown. We examined the effects of PTGS1 polymorphisms, smoking status, and their interaction on functional outcomes in a cohort of Chinese Han patients with stroke during aspirin therapy. Methods A total of 617 ischemic stroke patients taking aspirin were enrolled. Three single nucleotide polymorphisms (SNPs) rs1330344, rs3842788, and rs5788 in PTGS1 were determined for genotyping. Poor functional outcomes were defined as a modified Rankin Scale (mRS) of 3–6 at 90-day follow-up. The influence of PTGS1..
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Awarded by National Natural Science Foundation of China
Funding Acknowledgements
This study was supported by National Natural Science Foundation of China (81220108008, 81501193 and 81571148) and China Postdoctoral Science Foundation (2016M592954). We greatly appreciate Miss Ying Lin and Miss Zhaojun Wang in Jinling Hospital for their technical support.