Journal article

Genetic Imbalance in Patients with Cervical Artery Dissection

Caspar Grond-Ginsbach, Bowang Chen, Michael Krawczak, Rastislav Pjontek, Philip Ginsbach, Yanxiang Jiang, Sherine Abboud, Marie-Luise Arnold, Anna Bersano, Tobias Brandt, Valeria Caso, Stephanie Debette, Martin Dichgans, Andreas Geschwendtner, Giacomo Giacalone, Juan-Jose Martin, Antti J Metso, Tiina M Metso, Armin J Grau, Manja Kloss Show all



BACKGROUND: Genetic and environmental risk factors are assumed to contribute to the susceptibility to cervical artery dissection (CeAD). To explore the role of genetic imbalance in the etiology of CeAD, copy number variants (CNVs) were identified in high-density microarrays samples from the multicenter CADISP (Cervical Artery Dissection and Ischemic Stroke Patients) study and from control subjects from the CADISP study and the German PopGen biobank. Microarray data from 833 CeAD patients and 2040 control subjects (565 subjects with ischemic stroke due to causes different from CeAD and 1475 disease-free individuals) were analyzed. Rare genic CNVs were equally frequent in CeAD-patients (16.4%;..

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Awarded by Swiss National Science Foundation

Awarded by German Federal Ministry of Education and Research (BMBF)

Funding Acknowledgements

The CADISP study has been supported by Inserm, Lille 2 University, Institut Pasteur de Lille and Lille University Hospital and received funding from the Contrat de Projet Etat-Region 2007 Region Nord-Pas-de-Calais, Centre National de Genotypage, Emil Aaltonen Foundation, Paavo Ilmari Ahvenainen Foundation, Helsinki University Central Hospital Research Fund, Academy of Finland, Helsinki University Medical Foundation, Paivikki and Sakari Sohlberg Foundation, Aarne Koskelo Foundation, Maire Taponen Foundation, Aarne and Aili Turunen Foundation, Lilly Foundation, Alfred Kordelin Foundation, Finnish Medical Foundation, Biomedicum Helsinki Foundation, Maud Kuistila Foundation, Orion-Farmos Research Foundation, Finnish Brain Foundation Projet Hospitalier de Recherche Clinique Regional, Fondation de France, Genopole de Lille, Adrinord, Basel Stroke-Funds, Kathe-Zingg-Schwichtenberg-Fonds of the Swiss Academy of Medical Sciences, the Swiss National Science Foundation (33CM30-124119; 33CM30-140340/1) and the Swiss Heart Foundation. Vincent Thijs is supported by FWO Flanders. The PopGen biobank is funded by the State of Schleswig-Holstein and by the German Federal Ministry of Education and Research (BMBF) through a grant to the PopGen 2.0 Network (01EY1103).