Journal article
Increased aortic intima-media thickness following Kawasaki disease
KY Chen, D Zannino, N Curtis, M Cheung, D Burgner
Atherosclerosis | ELSEVIER IRELAND LTD | Published : 2017
Abstract
Background and aims The cardiovascular risk following Kawasaki disease (KD), especially in those without coronary artery changes or with regressed coronary artery lesions, is unclear. We assessed markers of early atherosclerosis in individuals following KD, including those with and without coronary artery abnormalities. Methods We performed a cross-sectional case-control study of 60 patients (25 with always normal coronary arteries and 35 with abnormalities) and 60 controls, at least two years after KD. Non-invasive assessment of arterial structure (carotid and aortic intima-media thickness (IMT)) and function (pulse wave velocity, carotid artery distensibility and diameter compliance) was d..
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by National Heart Foundation
Awarded by NHMRC
Awarded by Royal Children's Hospital Foundation
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
KYHC holds an Australian Postgraduate Award scholarship from The University of Melbourne and a Postgraduate Health Research Scholarship from Murdoch Childrens Research Institute. DPB holds a National Health and Medical Research Council (NHMRC) Senior Research Fellowship (APP1064629) and an honorary National Heart Foundation Future Leader Fellowship (100369). NC is an investigator on NHMRC project grant 1064408. Research at Murdoch Childrens Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The Heart Research Group is supported by The RCH1000, The Royal Children's Hospital Foundation and Big W. The sponsors had no involvement in the study design, collection, analysis, interpretation, and in the writing of this manuscript. Author contributions