Journal article

The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by 5-HTTLPR genotype

Marie-Laure Ancelin, Jacqueline Scali, Joanna Norton, Karen Ritchie, Anne-Marie Dupuy, Isabelle Chaudieu, Joanne Ryan



BACKGROUND: An adverse psychological environment (e.g. stressful events or depression) has been shown to influence basal cortisol levels and cortisol response to stress. This differs depending on the adverse stimuli, but also varies across individuals and may be influenced by genetic predisposition. An insertion/deletion polymorphism in the serotonin transporter gene (5-HTTLPR) is a strong candidate in this regard. OBJECTIVE: To investigate how stressful life events and depression are associated with diurnal cortisol levels in community-dwelling elderly and determine whether this varies according to genetic variability in the 5-HTTLPR. METHODS: This population-based study included 334 subjec..

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Awarded by Agence Nationale de la Recherche (ANR)

Funding Acknowledgements

The ESPRIT project is financed by the Agence Nationale de la Recherche (ANR) (grant 07 LVIE 004), and an unconditional grant from Novartis. The funders had no role in the design and conduct of the study; in data collection, management, analysis, interpretation of the data; or writing the report preparation, review, or approval of the manuscript.