Inhibiting the system x((C)over-bar)/glutathione axis selectively targets cancers with mutant-p53 accumulation
David S Liu, Cuong P Duong, Sue Haupt, Karen G Montgomery, Colin M House, Walid J Azar, Helen B Pearson, Oliver M Fisher, Matthew Read, Glen R Guerra, Ygal Haupt, Carleen Cullinane, Klas G Wiman, Lars Abrahmsen, Wayne A Phillips, Nicholas J Clemons
Nature Communications | NATURE PUBLISHING GROUP | Published : 2017
Awarded by National Health and Medical Research Council (NHMRC) of Australia Centres for Research Excellence Grant
Awarded by Victorian Cancer Agency Fellowship
Awarded by NHMRC
This work was supported by a National Health and Medical Research Council (NHMRC) of Australia Centres for Research Excellence Grant #1040947 (W.A.P.), a Translational Research Project Grant (TRP15012) from the Victorian Government Department of Health and Human Services through the Victorian Cancer Agency (W.A.P., N.J.C., C.P.D.), and a Peter MacCallum Cancer Foundation New Investigator grant (D.S.L.); D.S.L. was supported by Royal Australasian College of Surgeons (RACS) Foundation for Surgery John Loewenthal, Reg Worcester and Eric Bishop Fellowships, Cancer Therapeutics Scholarship (Cancer Therapeutics CRC) and NHMRC Postgraduate Research Scholarship; O.M.F. by a NHMRC Postgraduate Research Scholarship and a Swiss National Science Foundation Doc.Mobility Grant; M.R. by a RACS Thornell-Shore Memorial Scholarship and Melbourne University Sir Thomas Naghten Fitzgerald Scholarship; and G.R.G. by a RACS Foundation for Surgery Research Scholarship and a Covidien Colorectal Research Fellowship. N.J.C. is supported by a Victorian Cancer Agency Fellowship (MCRF16002) and an NHMRC Project Grant #1120293 (W.A.P., N.J.C., Y.H.). H.B.P. is supported by a Marie-Sklodowska Curie Actions/Ser Cymru COFUND fellowship. We thank Prof Johannes Zuber for providing the tet-inducible shRNA vector and Prof Ricky Johnstone, Prof Mark Dawson, Dr Daniella Brasacchio, Dr Liz Christie, and the Peter MacCallum Cancer Centre FACS, microscopy, functional genomics and animal core facilities, for their advice and/or technical assistance.