Journal article

High serum vitamin D level correlates with better prognostic indicators in primary melanoma: A pilot study

Alvin Lim, Ramin Shayan, George Varigos

AUSTRALASIAN JOURNAL OF DERMATOLOGY | WILEY | Published : 2018

Abstract

BACKGROUND/OBJECTIVES: Sunlight is a major risk factor for cutaneous melanoma. However, its interaction with melanoma is complex. In particular, vitamin D is a UVB-derived hormone that has been shown to have anti-cancer effects. In this retrospective pilot study we sought to determine an association between the clinicopathological features of melanoma and the patients' corresponding serum vitamin D level. METHODS: In total, 109 primary melanomas diagnosed between 2001 and 2013 were retrospectively identified from our institutional database with a corresponding 25-hydroxyvitamin D3 level estimated within 6 months of diagnosis. Tumour, clinical (age, sex, tumour location) and pathological (thi..

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