Gastrointestinal Carriage Is a Major Reservoir of Klebsiella pneumoniae Infection in Intensive Care Patients
Claire L Gorrie, Mirjana Mirceta, Ryan R Wick, David J Edwards, Nicholas R Thomson, Richard A Strugnell, Nigel F Pratt, Jill S Garlick, Kerri M Watson, David V Pilcher, Steve A McGloughlin, Denis W Spelman, Adam WJ Jenney, Kathryn E Holt
Clinical Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2017
Background: Klebsiella pneumoniae is an opportunistic pathogen and leading cause of hospital-associated infections. Intensive care unit (ICU) patients are particularly at risk. Klebsiella pneumoniae is part of the healthy human microbiome, providing a potential reservoir for infection. However, the frequency of gut colonization and its contribution to infections are not well characterized. Methods: We conducted a 1-year prospective cohort study in which 498 ICU patients were screened for rectal and throat carriage of K. pneumoniae shortly after admission. Klebsiella pneumoniae isolated from screening swabs and clinical diagnostic samples were characterized using whole genome sequencing and c..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia (Project 1043822 and Fellowship 1061409 to K. E. H.) and the Australian Government Research Training Program (Scholarship to C. L. G.).