Journal article

A phylogenomic framework for assessing the global emergence and evolution of clonal complex 398 methicillin-resistant Staphylococcus aureus

Anders Goncalves da Silva, Sarah L Baines, Glen P Carter, Helen Heffernan, Nigel P French, Xiaoyun Ren, Torsten Seemann, Dieter Bulach, Jason Kwong, Timothy P Stinear, Benjamin P Howden, Deborah A Williamson

MICROBIAL GENOMICS | MICROBIOLOGY SOC | Published : 2017

Abstract

Distinct clones of methicillin-resistant Staphylococcus aureus (MRSA) have emerged as important causes of infection in individuals who have exposure to livestock (livestock-associated MRSA; LA-MRSA). Clonal complex 398 (CC398) is the most prevalent LA-MRSA clone, and has been reported from several geographical settings, including Europe, the Americas and Asia. To understand the factors contributing to the global dissemination of this clone, we analysed CC398 MRSA isolates from New Zealand (NZ), a geographically isolated country with an economy strongly dependent on livestock farming. We supplemented the NZ CC398 MRSA collection with global datasets of CC398 MRSA and CC398 methicillin-suscept..

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia


Awarded by NHMRC, Australia


Funding Acknowledgements

Doherty Applied Microbial Genomics is funded by the Department of Microbiology and Immunology at The University of Melbourne. The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Department of Health and Human Services, Victoria. B. P. H. is funded by a Fellowship from the National Health and Medical Research Council (NHMRC), Australia (GNT1105905). D.A.W. is funded by a Fellowship from the NHMRC, Australia (GNT1123854).