Journal article

Renovascular hypertension - Structural changes in the renal vasculature

WP Anderson, MM Kett, KM Stevenson, AJ Edgley, KM Denton, SM Fitzgerald

Hypertension | LIPPINCOTT WILLIAMS & WILKINS | Published : 2000


Experimental narrowing of the main renal artery to produce hypertension increases the aorta-glomerular capillary pressure difference and vascular resistance. This article examines the hypothesis that hypertension also may be caused by structural changes that narrow intrarenal blood vessels, similarly increasing preglomerular vascular resistance and the aortic-glomerular capillary pressure gradient. There is evidence of both wall hypertrophy and lumen narrowing of the preglomerular arteries in spontaneously hypertensive rats, with increased preglomerular resistance and aortic-glomerular capillary pressure difference. We have also attempted to induce structural changes in renal-preglomerular v..

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