Currents of memory: recent progress, translational challenges, and ethical considerations in fornix deep brain stimulation trials for Alzheimer's disease
John Noel M Viana, James C Vickers, Mark J Cook, Frederic Gilbert
NEUROBIOLOGY OF AGING | ELSEVIER SCIENCE INC | Published : 2017
The serendipitous discovery of triggered autobiographical memories and eventual memory improvement in an obese patient who received fornix deep brain stimulation in 2008 paved the way for several phase I and phase II clinical trials focused on the safety and efficacy of this potential intervention for people with Alzheimer's disease. In this article, we summarize clinical trials and case reports on fornix deep brain stimulation for Alzheimer's disease and review experiments on animal models evaluating the physiological or behavioral effects of this intervention. Based on information from these reports and studies, we identify potential translational challenges of this approach and determine ..View full abstract
Awarded by Australian Research Council Discovery Early Career Researcher Award
Awarded by Australian Research Council Centre of Excellence Scheme
This work is supported by the Tasmania Graduate Research Scholarship awarded by the University of Tasmania to Mr. Viaa. Dr. Frederic Gilbert is the recipient of an Australian Research Council Discovery Early Career Researcher Award (project number DE150101390). Funding from the Australian Research Council Centre of Excellence Scheme (Project Number CE 140100012) is gratefully acknowledged.