Journal article
Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study
SK Patel, C Restrepo, E Werden, L Churilov, EI Ekinci, PM Srivastava, J Ramchand, B Wai, B Chambers, CJ O'Callaghan, D Darby, V Hachinski, T Cumming, G Donnan, LM Burrell, A Brodtmann
BMC Endocrine Disorders | BMC | Published : 2017
Open access
Abstract
Background: Cognitive impairment is common in type 2 diabetes mellitus, and there is a strong association between type 2 diabetes and Alzheimer's disease. However, we do not know which type 2 diabetes patients will dement or which biomarkers predict cognitive decline. Left ventricular hypertrophy (LVH) is potentially such a marker. LVH is highly prevalent in type 2 diabetes and is a strong, independent predictor of cardiovascular events. To date, no studies have investigated the association between LVH and cognitive decline in type 2 diabetes. The Diabetes and Dementia (D2) study is designed to establish whether patients with type 2 diabetes and LVH have increased rates of brain atrophy and ..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The study has been funded by the National Health and Medical Research Council of Australia (application ID, APP1094974).