Journal article

Blood pressure and risk of breast cancer, overall and by subtypes: a prospective cohort study

Yi Yang, Brigid M Lynch, Allison M Hodge, Danny Liew, Catriona A Mclean, Mathias Seviiri, Melissa C Southey, John L Hopper, Dallas R English, Graham G Giles, Roger L Milne, Pierre-Antoine Dugue



OBJECTIVE: Blood pressure (BP) and breast cancer may share a common pathophysiologic pathway involving chronic inflammation, hormone synthesis and metabolism. Previous studies investigating the association between BP and breast cancer measured BP at a single time point and did not examine associations by breast cancer molecular subtypes. METHODS: We used data from 22 833 female participants in the Melbourne Collaborative Cohort Study. BP was objectively measured at baseline (1990-1994) and a follow-up visit (2003-2007). Cox regression was used to estimate hazard ratios for baseline BP and temporal changes in BP in relation to risk of breast cancer, overall and by molecular subtypes. RESULTS:..

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Awarded by Australian NHMRC grants

Awarded by National Breast Cancer Foundation

Funding Acknowledgements

MCCS cohort recruitment was funded by VicHealth and Cancer Council Victoria. The MCCS was further supported by Australian NHMRC grants 209057, 251553 and 504711, and by infrastructure provided by Cancer Council Victoria. Cases and their vital status were ascertained through the Victorian Cancer Registry (VCR) and the Australian Institute of Health and Welfare (AIHW), including the National Death Index and the Australian Cancer Database. Brigid Lynch is supported by a Fellowship from the National Breast Cancer Foundation (ECF-15-012).