Glycine metabolism in skeletal muscle: implications for metabolic homeostasis
Rene Koopman, Marissa K Caldow, Daniel J Ham, Gordon S Lynch
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
PURPOSE OF REVIEW: The review summarizes the recent literature on the role of glycine in skeletal muscle during times of stress. RECENT FINDINGS: Supplemental glycine protects muscle mass and function under pathological conditions. In addition, mitochondrial dysfunction in skeletal muscle leads to increased cellular serine and glycine production and activation of NADPH-generating pathways and glutathione metabolism. These studies highlight how glycine availability modulates cellular homeostasis and redox status. SUMMARY: Recent studies demonstrate that supplemental glycine effectively protects muscles in a variety of wasting models, including cancer cachexia, sepsis, and reduced caloric inta..View full abstract
Awarded by National Health and Medical Research Council, Australia
Funding to pursue this research has been provided by a grant from the National Health and Medical Research Council, Australia (APP1103571) to R.K. and G.S.L. M.K.C. is supported by a McKenzie Fellowship from the University of Melbourne. R.K., D.J.H., and M.K.C. were supported by fellowships from the European Society for Clinical Nutrition and Metabolism (ESPEN).