Journal article

Glycine metabolism in skeletal muscle: implications for metabolic homeostasis

Rene Koopman, Marissa K Caldow, Daniel J Ham, Gordon S Lynch

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017

Abstract

PURPOSE OF REVIEW: The review summarizes the recent literature on the role of glycine in skeletal muscle during times of stress. RECENT FINDINGS: Supplemental glycine protects muscle mass and function under pathological conditions. In addition, mitochondrial dysfunction in skeletal muscle leads to increased cellular serine and glycine production and activation of NADPH-generating pathways and glutathione metabolism. These studies highlight how glycine availability modulates cellular homeostasis and redox status. SUMMARY: Recent studies demonstrate that supplemental glycine effectively protects muscles in a variety of wasting models, including cancer cachexia, sepsis, and reduced caloric inta..

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Grants

Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

Funding to pursue this research has been provided by a grant from the National Health and Medical Research Council, Australia (APP1103571) to R.K. and G.S.L. M.K.C. is supported by a McKenzie Fellowship from the University of Melbourne. R.K., D.J.H., and M.K.C. were supported by fellowships from the European Society for Clinical Nutrition and Metabolism (ESPEN).