Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner

SL Gardener; SR Rainey-Smith; HR Sohrabi; M Weinborn; G Verdile; WMADB Fernando; YY Lim; K Harrington; S Burnham; K Taddei; CL Masters; SL Macaulay; CC Rowe; D Ames; P Maruff; RN Martins

Journal article

Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner

SL Gardener, SR Rainey-Smith, HR Sohrabi, M Weinborn, G Verdile, WMADB Fernando, YY Lim, K Harrington, S Burnham, K Taddei, CL Masters, SL Macaulay, CC Rowe, D Ames, P Maruff, RN Martins

Journal of Alzheimer S Disease | IOS PRESS | Published : 2017

DOI: 10.3233/JAD-161158

Abstract

Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ϵ4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-β (Aβ) load in CN older adults, genotyped for APOE ϵ4 allele carrier status. Greater carbohydrate intake was associated with poorer performance in verbal memory in APOE ϵ4 allele non-carriers, and poorer performance in attention in APOE ϵ4 allele ca..

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University of Melbourne Researchers

Christopher Rowe Author

David Ames Author

Paul Maruff Author

Grants

Awarded by Curtin University Senior Research Fellowship

Awarded by NHMRC

Funding Acknowledgements

Funding for the study was provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), The Florey Institute of Neuroscience and Mental Health, Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd., Hollywood Private Hospital, and Sir Charles Gairdner Hospital. The study also received funding from the National Health and Medical Research Council (NHMRC), the Dementia Collaborative Research Centres program (DCRC2) and the McCusker Alzheimer's Research Foundation and Operational Infrastructure Support from the Government of Victoria. GV is supported by the Curtin University Senior Research Fellowship (CRF140196) and the NHMRC (APP1045507 and APP1105698).