Journal article

Synergistic targeting of breast cancer stem-like cells by human gamma delta T cells and CD8( ) T cells

Hung-Chang Chen, Noemie Joalland, John S Bridgeman, Fouad S Alchami, Ulrich Jarry, Mohd Wajid A Khan, Luke Piggott, Yasmin Shanneik, Jianqiang Li, Marco J Herold, Thomas Herrmann, David A Price, Awen M Gallimore, Richard W Clarkson, Emmanuel Scotet, Bernhard Moser, Matthias Eberl

Immunology & Cell Biology | WILEY | Published : 2017

University of Melbourne Researchers


Awarded by Cancer Research UK

Awarded by Institut National du Cancer

Awarded by Wilhelm Sander-Stiftung

Awarded by Wellcome Trust

Awarded by Investissements d'Avenir (Agence Nationale de la Recherche-Programme Laboratoires d'Excellence Immunotherapy Graft Oncology)

Funding Acknowledgements

We would like to thank Robert Weinberg for providing HLMER cells; James Riley and Mai Ping Tan for plasmids; Andrew Thomas for recombinant FluM1 protein and HLA-A2 tetramers; Fariba Navid for hu14.18K322A antibodies; Daniel Olive for BTN3A blocking antibodies; Hassan Jomaa for synthetic HMB-PP; Nooshin Tabatabaei-Zavareh for custom-made gamma delta T-cell isolation kits; Catherine Naseriyan, Kelly Miners and Kristin Ladell for cell sorting; Aled Clayton for help with confocal microscopy; Tamsin Dockree, Chia-Te Liao and Lisa Starick for help with lentiviral constructs; Emily Colbeck, Emma Jones and Anwen Williams for help with histology; Garry Dolton, Ellyn Hughes and Emma Kempshall for help with animal studies; and the Cellular and Tissular Imaging Core Facility of Nantes University (MicroPICell) and Lola Boutin for help with video microscopy and calcium experiments. This research was supported by the Wales Cancer Research Centre and the Cardiff CR-UK Centre Development Fund; Cancer Research UK grants C28524/A9497, C42921/A13823 and C16731/A21200; Institut National de la Sante et de la Recherche Medicale (INSERM); Centre National de la Recherche Scientifique (CNRS); Universite de Nantes; Institut National du Cancer (INCa PLBIO 2014-155) and Investissements d'Avenir (Agence Nationale de la Recherche-Programme Laboratoires d'Excellence Immunotherapy Graft Oncology; #ANR 11 LABX-0016-01); Wilhelm Sander-Stiftung grant 2013.907.1; Tenovus PhD Studentships to H-CC and LP; a Government Scholarship for Study Abroad from the Taiwanese Ministry of Education (H-CC); an Erasmus+ Traineeship (YS); and a Cardiff Incoming Visiting Fellowship (TH). DAP is supported by a Wellcome Trust Senior Investigator Award (100326/Z/12/Z).