Journal article

Antifibrillarin Antibodies Are Associated with Native North American Ethnicity and Poorer Survival in Systemic Sclerosis

Carolina Mejia Otero, Shervin Assassi, Marie Hudson, Maureen D Mayes, Rosa Estrada-Y-Martin, Claudia Pedroza, Tingting W Mills, Jennifer Walker, Murray Baron, Wendy Stevens, Susanna M Proudman, Mandana Nikpour, Sonal Mehra, Mianbo Wang, Marvin J Fritzler

JOURNAL OF RHEUMATOLOGY | J RHEUMATOL PUBL CO | Published : 2017

Abstract

OBJECTIVE: To examine the clinical correlates and survival in patients with antifibrillarin antibodies (AFA) in a large international study population consisting of well-characterized systemic sclerosis (SSc) cohorts from Canada, Australia, and the United States. METHODS: Baseline clinical data from the prospective cohorts (Canadian Scleroderma Research Group, the Australian Scleroderma Cohort Study, and the American Genetics versus Environment in Scleroderma Outcome Study) were investigated. Clinical variables were harmonized and sera were tested for AFA using a commercially available SSc profile line immunoassay, regardless of the immunofluorescence staining pattern. Association of demogra..

View full abstract

Grants

Awarded by National Health and Medical Research Council


Awarded by US National Institutes of Health (NIH)/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)


Awarded by NIH/NIAMS


Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES


Funding Acknowledgements

Dr. Hudson is funded by the Fonds de la recherche en sante du Quebec. Dr. Nikpour holds a University of Melbourne Faculty of Medicine Dentistry and Health Science David Bickart Clinician Researcher Fellowship, and is a recipient of a National Health and Medical Research Council research fellowship (APP1071735). Dr. Assassi is funded by the US National Institutes of Health (NIH)/US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K23AR061436. Dr. Mayes is funded by NIH/NIAMS AR055258.