Single-specificity anti-Ku antibodies in an international cohort of 2140 systemic sclerosis subjects: clinical associations
S Hoa, M Hudson, Y Troyanov, S Proudman, J Walker, W Stevens, M Nikpour, S Assassi, MD Mayes, M Wang, M Baron, MJ Fritzler
MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016
Autoantibodies directed against the Ku autoantigen are present in systemic sclerosis (SSc) and have been associated with myositis overlap and interstitial lung disease (ILD). However, there is a paucity of data on the clinical correlates of anti-Ku antibodies in the absence of other SSc-specific antibodies. The aim of this study was to assess the clinical correlates of single-specificity anti-Ku in SSc.An international (Canada, Australia, USA, Mexico) cohort of 2140 SSc subjects was formed, demographic and clinical variables were harmonized, and sera were tested for anti-Ku using a line immunoassay. Associations between single-specificity anti-Ku antibodies (i.e., in isolation of other SSc-s..View full abstract
Awarded by Canadian Institutes of Health Research (CIHR)
Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
The CSRG received funds and/or gifts in kind from the Canadian Institutes of Health Research (CIHR) (grant n. FRN 83518), the Scleroderma Society of Canada and its provincial Chapters, Scleroderma Society of Ontario, Sclerodermie Quebec, Cure Scleroderma Foundation, Scleroderma Society of Saskatchewan, INOVA Diagnostics Inc. (San Diego, CA), Euroimmun (Lubeck, Germany), Fonds de la recherche en sante du Quebec (FRSQ), the Canadian Arthritis Network (CAN), the Arthritis Society Research Chair (University of Calgary) and the Lady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, QC.