Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen
Milena M Awad, Priscilla A Johanesen, Glen P Carter, Edward Rose, Dena Lyras
Gut Microbes | TAYLOR & FRANCIS INC | Published : 2014
The worldwide emergence of epidemic strains of Clostridium difficile linked to increased disease severity and mortality has resulted in greater research efforts toward determining the virulence factors and pathogenesis mechanisms used by this organism to cause disease. C. difficile is an opportunist pathogen that employs many factors to infect and damage the host, often with devastating consequences. This review will focus on the role of the 2 major virulence factors, toxin A (TcdA) and toxin B (TcdB), as well as the role of other putative virulence factors, such as binary toxin, in C. difficile-mediated infection. Consideration is given to the importance of spores in both the initiation of ..View full abstract
The researchers were supported by Project Grants from the Australian National Health and Medical Research Council (NHMRC). DL was supported by an ARC Future Fellowship from the Australian Research Council (ARC).