The role of toxin A and toxin B in the virulence of Clostridium difficile
Glen P Carter, Julian I Rood, Dena Lyras
TRENDS IN MICROBIOLOGY | ELSEVIER SCI LTD | Published : 2012
During the past decade, there has been a striking increase in Clostridium difficile nosocomial infections worldwide predominantly due to the emergence of epidemic or hypervirulent isolates, leading to an increased research focus on this bacterium. Particular interest has surrounded the two large clostridial toxins encoded by most virulent isolates, known as toxin A and toxin B. Toxin A was thought to be the major virulence factor for many years; however, it is becoming increasingly evident that toxin B plays a much more important role than anticipated. It is clear that further experiments are required to accurately determine the relative roles of each toxin in disease, especially in more cli..View full abstract
This work was supported by Project Grants from the Australian National Health and Medical Research Council and a Discovery Grant from the Australian Research Council.