Journal article
The anti-sigma factor tcdc modulates hypervirulence in an epidemic BI/NAP1/027 clinical isolate of clostridium difficile
GP Carter, GR Douce, R Govind, PM Howarth, KE Mackin, J Spencer, AM Buckley, A Antunes, D Kotsanas, GA Jenkin, B Dupuy, JI Rood, D Lyras
Plos Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
Nosocomial infections are increasingly being recognised as a major patient safety issue. The modern hospital environment and associated health care practices have provided a niche for the rapid evolution of microbial pathogens that are well adapted to surviving and proliferating in this setting, after which they can infect susceptible patients. This is clearly the case for bacterial pathogens such as Methicillin Resistant Staphylococcus aureus (MRSA) and Vancomycin Resistant Enterococcus (VRE) species, both of which have acquired resistance to antimicrobial agents as well as enhanced survival and virulence properties that present serious therapeutic dilemmas for treating physicians. It has r..
View full abstractGrants
Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This work was supported by Project Grants from the Australian National Health and Medical Research Council and the Australian Research Council (Monash University), Grant AI057637 from the United States National Institute of Allergy and Infectious Diseases (Monash University and Institut Pasteur) and by Project and Programme Grants from Institut Pasteur, The Wellcome Trust and a personal fellowship for GRD from the Royal Society of Edinburgh (Glasgow University). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.