Journal article
Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia
Seth T Walk, Ruchika Jain, Itishree Trivedi, Sylvia Grossman, Duane W Newton, Tennille Thelen, Yibai Hao, J Glenn Songer, Glen P Carter, Dena Lyras, Vincent B Young, David M Aronoff
ANAEROBE | ELSEVIER SCI LTD | Published : 2011
Abstract
Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or t..
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Awarded by National Institutes of Health, National Center for Research Resources
Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES
Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Funding Acknowledgements
This work was supported by National Institutes of Health grant HL078727 (D.M.A.) and UL1RR024986 (S.T.W.) from the National Center for Research Resources. The non-animal research was supported by a Doris Duke Charitable Foundation Clinical Scientist Development Award (D.M.A.).