Journal article

Non-toxigenic Clostridium sordellii: Clinical and microbiological features of a case of cholangitis-associated bacteremia

Seth T Walk, Ruchika Jain, Itishree Trivedi, Sylvia Grossman, Duane W Newton, Tennille Thelen, Yibai Hao, J Glenn Songer, Glen P Carter, Dena Lyras, Vincent B Young, David M Aronoff

ANAEROBE | ELSEVIER SCI LTD | Published : 2011

Abstract

Toxigenic Clostridium sordellii strains are increasingly recognized to cause highly lethal infections in humans that are typified by a toxic shock syndrome (TSS). Two glucosylating toxins, lethal toxin (TcsL) and hemorrhagic toxin (TcsH) are believed to be important in the pathogenesis of TSS. While non-toxigenic strains of C. sordellii demonstrate reduced cytotoxicity in vitro and lower virulence in animal models of infection, there are few data regarding their behavior in humans. Here we report a non-TSS C. sordellii infection in the context of a polymicrobial bacterial cholangitis. The C. sordellii strain associated with this infection did not carry either the TcsL-encoding tcsL gene or t..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health, National Center for Research Resources


Awarded by EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

This work was supported by National Institutes of Health grant HL078727 (D.M.A.) and UL1RR024986 (S.T.W.) from the National Center for Research Resources. The non-animal research was supported by a Doris Duke Charitable Foundation Clinical Scientist Development Award (D.M.A.).