Journal article
Weight loss after laparoscopic adjustable gastric band and resolution of the metabolic syndrome and its components
GJ Ooi, L Doyle, T Tie, JM Wentworth, C Laurie, A Earnest, MA Cowley, K Sikaris, CW Le Roux, PR Burton, PE O'Brien, WA Brown
International Journal of Obesity | SPRINGERNATURE | Published : 2017
DOI: 10.1038/ijo.2017.59
Abstract
Background:Substantial weight loss in the setting of obesity has considerable metabolic benefits. Yet some studies have shown improvements in obesity-related metabolic comorbidities with more modest weight loss. By closely monitoring patients undergoing bariatric surgery, we aimed to determine the effects of weight loss on the metabolic syndrome and its components and determine the weight loss required for their resolution.Methods:We performed a prospective observational study of obese participants with metabolic syndrome (Adult Treatment Panel III criteria) who underwent laparoscopic adjustable gastric banding. Participants were assessed for all criteria of the metabolic syndrome monthly fo..
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Funding Acknowledgements
GJO, LD, TT, CL, PRB, PEO'B and WAB report being affiliated with the Centre for Obesity Research and Education. The Centre has received funding for research purposes from Allergan and Apollo Endosurgery, the manufacturers of the LapBand. The grant is not tied to any specific research project, and Allergan has no control of the protocol, analysis and reporting of any studies. CORE also receives a grant from Applied Medical towards educational programs. WAB reports financial support for a bariatric surgery registry from the Commonwealth of Australia, Apollo Endosurgery, Covidien, Johnson and Johnson, Gore and Applied Medical and a speaker's honorarium from Merck Sharpe and Dohme. These are outside of the submitted work. MAC reports grants and personal fees from Novo Nordisk, personal fees and other from Orexigen Therapeutics, outside the submitted work. KS is the Director of Clinical Support Services at Sonic Healthcare; this is unrelated to this work. CWlR has received funding from the Science Foundation Ireland (12/YI/B2480). He also serves on the advisory boards of NovoNordisk and Herbalife and has received speakers fees from Ethicon EndoSurgery. GJO and LD report scholarships from the National Health and Medical Research Council and the Royal Australasian College of Surgeons. PEO'B has written a patient information book entitled 'The Lap-Band Solution: A partnership for weight loss', which is given to patients without charge, but some are sold to surgeons and others, for which he receives a royalty. JMW and AE have no other relevant disclosures.