Journal article

042.The role of TGF-β in normal and pathological lens development

JW McAvoy, FJ Lovicu, RU De Iongh

Reproduction Fertility and Development | CSIRO Publishing | Published : 2004


How the lens develops its highly ordered architecture and growth patterns is a major question in developmental biology. During embryogenesis, cells in the anterior and posterior segments of the lens vesicle, differentiate into the epithelial and fibre cells, respectively. Our research has aimed to identify the molecules and mechanisms that regulate the divergent fates of lens cells. We have studied the roles of various growth factors in regulating lens cell fates using rat lens epithelial explant cultures and transgenic and mutant mouse models. Our research has shown that members of the FGF growth factor family are key initiators of lens fibre differentiation in mammals and there is now comp..

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University of Melbourne Researchers