Journal article
Muscle characteristics in patients with chronic systemic inflammation
KGM Beenakker, BJ Duijnisveld, HMJ Van Der Linden, CPJ Visser, RGJ Westendorp, G Butler-Brown, RGHH Nelissen, AB Maier
Muscle and Nerve | WILEY-BLACKWELL | Published : 2012
DOI: 10.1002/mus.23291
Abstract
Introduction: Histological characteristics of age-related muscle wasting are type II muscle fiber atrophy, accumulation of oxidative stress-induced lipofuscin granules and decreased satellite cell numbers. There is increasing clinical evidence for a strong correlation between chronic systemic inflammation and age-related muscle wasting. The aim of this study was to determine the impact of chronic systemic inflammation on age-related histological muscle characteristics. Methods: As a model for chronic systemic inflammation, we included 10 patients suffering from rheumatoid arthritis (RA) and 27 control patients suffering from osteoarthritis (OA). Biopsies were taken from the vastus medialis m..
View full abstractGrants
Awarded by Ministry of Health, Welfare and Sports
Awarded by Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO)
Awarded by seventh framework program MYOAGE
Funding Acknowledgements
We thank H.J.L. van der Heide, Q. G. B. Feilzer, S. H. M. Verdegaal, and E.J. van Langelaan for obtaining muscle biopsies, C. de Koning-Treurniet and J. Blom for muscle biopsy handling, R. den Arend for histological staining assistance and analysis, E. Negroni for improving staining techniques, J. Vrolijk for developing image analysis software. This work was supported by the Translational Research Programme from the Netherlands Organization of Scientific Research (ZonMw), the Ministry of Health, Welfare and Sports (project number 95100105), the Dutch Arthritis Association (LRR), the Netherlands Genomics Initiative/Netherlands Organization for scientific research (NGI/NWO; 05040202 and 050-060-810 Netherlands Consortium for Healthy Ageing (NCHA)) and the seventh framework program MYOAGE (HEALTH-2007-2.4.5-10).