Journal article

Connectomic correlates of response to treatment in first-episode psychosis

Nicolas A Crossley, Tiago Reis Marques, Heather Taylor, Chris Chaddock, Flavio Dell'Acqua, Antje ATS Reinders, Valeria Mondelli, Marta DiForti, Andrew Simmons, Anthony S David, Shitij Kapur, Carmine M Pariante, Robin M Murray, Paola Dazzan

BRAIN | OXFORD UNIV PRESS | Published : 2017


Connectomic approaches using diffusion tensor imaging have contributed to our understanding of brain changes in psychosis, and could provide further insights into the neural mechanisms underlying response to antipsychotic treatment. We here studied the brain network organization in patients at their first episode of psychosis, evaluating whether connectome-based descriptions of brain networks predict response to treatment, and whether they change after treatment. Seventy-six patients with a first episode of psychosis and 74 healthy controls were included. Thirty-three patients were classified as responders after 12 weeks of antipsychotic treatment. Baseline brain structural networks were bui..

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University of Melbourne Researchers


Awarded by Chilean CONICYT

Awarded by MRC

Awarded by Academy of Medical Sciences (AMS)

Awarded by Medical Research Council

Awarded by National Institute for Health Research

Funding Acknowledgements

This work was supported by the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and the Institute of Psychiatry, Psychology and Neuroscience, King's College London. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. The study was also partially supported by a King's College London Translational Research Grant to P.D. N.A.C. received support from the Chilean CONICYT (PIA ACT1414 and FONDECYT 1160736). T.R.M. and P.D.'s research are supported by NARSAD. T.M., C.C., M.D. and P.D. were funded partly by the Psychiatry Research Trust.