Journal article
Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies
DR Brenner, A Fanidi, K Grankvist, DC Muller, P Brennan, J Manjer, G Byrnes, A Hodge, G Severi, GG Giles, M Johansson, M Johansson
American Journal of Epidemiology | OXFORD UNIV PRESS INC | Published : 2017
DOI: 10.1093/aje/kww159
Abstract
To further investigate the role of inflammation in lung carcinogenesis, we evaluated associations between proinflammatory cytokines and lung cancer risk. We conducted a case-control study nested within 3 prospective cohort studies-the Melbourne Collaborative Cohort Study (1990-1994), the Malm- Diet and Cancer Study (1991-1996), and the Northern Sweden Health and Disease Study (initiated in 1985)-involving 807 incident lung cancer cases and 807 smoking-matched controls. Conditional logistic regression models adjusting for serum cotinine concentrations were used to estimate odds ratios for lung cancer risk associated with concentrations of interleukin (IL)-1-, IL-2, IL-6, IL-8, IL-10, IL-12, i..
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Awarded by Canadian Cancer Society Research Institute
Funding Acknowledgements
This work was funded by the Swedish Cancer Society (Principal Investigators: T. Rasmuson, M. Johansson). D.B. was supported by a Capacity Development Award in Cancer Prevention from the Canadian Cancer Society Research Institute (grant 703917).