Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
Shiraz Tyebji, Anthony J Hannan
PROGRESS IN NEUROBIOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Dementia encapsulates a set of symptoms that include loss of mental abilities such as memory, problem solving or language, and reduces a person's ability to perform daily activities. Alzheimer's disease is the most common form of dementia, however dementia can also occur in other neurological disorders such as Huntington's disease (HD). Many studies have demonstrated that loss of neuronal cell function manifests pre-symptomatically and thus is a relevant therapeutic target to alleviate symptoms. Synaptopathy, the physiological dysfunction of synapses, is now being approached as the target for many neurological and psychiatric disorders, including HD. HD is an autosomal dominant and progressi..View full abstract
We thank members of the Hannan Laboratory, past and present, for helpful discussions that have contributed to preparation of this manuscript. The research in this laboratory has been supported by the NHMRC via Project Grants (AJH) and a Huntington's Disease Research Project grant from the Macquarie Group Foundation (AJH). AJH is an NHMRC Principal Research Fellow.