Intravenous sodiumnitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI)
Nishat Siddiqi, Christopher Neil, Margaret Bruce, Graeme MacLennan, Seonaidh Cotton, Sofia Papadopoulou, Martin Feelisch, Nicholas Bunce, Pitt O Lim, David Hildick-Smith, John Horowitz, Melanie Madhani, Nicholas Boon, Dana Dawson, Juan Carlos Kaski, Michael Frenneaux
EUROPEAN HEART JOURNAL | OXFORD UNIV PRESS | Published : 2014
AIM: Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this double-blind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: A total of 229 patients presenting with acute STEMI were randomized to receive either an i.v. infusion of 70 μmol sodium nitr..View full abstract
Awarded by MRC
Awarded by Chief Scientist Office
Awarded by Medical Research Council
This study was funded by the UK Medical Research Council. Funding to pay the Open Access publication charges for this article was provided by the University of Aberdeen.