No association of G-protein-coupled receptor kinase 5 or -adrenergic receptor polymorphisms with Takotsubo cardiomyopathy in a large Australian cohort
Gemma A Figtree, Richard D Bagnall, Irfan Abdulla, Stefan Buchholz, Keyvan Karimi Galougahi, Warren Yan, Timothy Tan, Chris Neil, John D Horowitz, Chris Semsarian, Michael R Ward
EUROPEAN JOURNAL OF HEART FAILURE | OXFORD UNIV PRESS | Published : 2013
AIMS: Takotsubo cardiomyopathy (TC) is an increasingly recognized syndrome in which patients present with chest pain and ST changes, and are observed to have reversible LV apical ballooning in the absence of angiographically significant coronary artery stenosis. Although the pathophysiology remains unclear, the syndrome occurs almost exclusively in women, and is often triggered by stress. Recent small studies have reported association of TC with functional variants in the G-protein-coupled receptor kinase 5 (GRK5) gene, as well as in the β1-adrenergic receptor (β1AR) and β2AR. METHODS AND RESULTS: We tested these associations in a larger cohort of 92 TC patients. In addition we examined for ..View full abstract
The National Health and Medical Research Council of Australia and North Shore Heart Research Foundation. G.A.F. was supported by the Medical Foundation, University of Sydney. C.S. is a recipient of an NHMRC Practitioner Fellowship.