Journal article
Slowly resolving global myocardial inflammation/oedema in Tako-Tsubo cardiomyopathy: evidence from T2-weighted cardiac MRI
Christopher Neil, Ha Nguyen Thanh, Angela Kucia, Benjamin Crouch, Aaron Sverdlov, Yuliy Chirkov, Gnanadevan Mahadavan, Joseph Selvanayagam, Dana Dawson, John Beltrame, Christopher Zeitz, Steven Unger, Thomas Redpath, Michael Frenneaux, John Horowitz
HEART | BMJ PUBLISHING GROUP | Published : 2012
Abstract
OBJECTIVE: Tako-Tsubo cardiomyopathy (TTC) is associated with regional left ventricular dysfunction, independent of the presence of fixed coronary artery disease. Previous studies have used T2-weighted cardiac MRI to demonstrate the presence of periapical oedema. The authors sought to determine the distribution, resolution and correlates of oedema in TTC. PATIENTS: 32 patients with TTC were evaluated at a median of 2 days after presentation, along with 10 age-matched female controls. Extent of oedema was quantified both regionally and globally; scanning was repeated in patients with TTC after 3 months. Correlations were sought between oedema and the extent of hypokinesis, catecholamine relea..
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Funding Acknowledgements
This study was supported in part by a research grant from the National Health and Medical Research Council of Australia. CJN was the recipient of an Australian Postgraduate Award scholarship and a CVL Cardiovascular and Lipid research grant. THN held a University of Adelaide Endeavour International Postgraduate Research Scholarship.