N-Terminal Pro-Brain Natriuretic Protein Levels in Takotsubo Cardiomyopathy
Thanh Ha Nguyen, Christopher J Neil, Aaron L Sverdlov, Gnanadevan Mahadavan, Yuliy Y Chirkov, Angela M Kucia, Jeanette Stansborough, John F Beltrame, Joseph B Selvanayagam, Christopher J Zeitz, Allan D Struthers, Michael P Frenneaux, John D Horowitz
AMERICAN JOURNAL OF CARDIOLOGY | EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC | Published : 2011
Takotsubo cardiomyopathy (TTC) is characterized by reversible left ventricular (LV) systolic dysfunction independent of fixed coronary disease or coronary spastic pathogenesis. A number of investigators have documented marked elevation of natriuretic peptide levels at presentation in such patients. We sought to determine the pattern, extent, and determinants of the release of N-terminal pro-B type natriuretic peptide/B type natriuretic peptide (NT-proBNP/BNP) in patients with TTC. We evaluated NT-proBNP/BNP release acutely and during the first 3 months in 56 patients with TTC (96% women, mean age 69 ± 11 years). The peak plasma NT-proBNP levels were compared to the pulmonary capillary wedge ..View full abstract
This study was funded in part by a grant from the National Health and Medical Research Council of Australia. Dr. Nguyen was a recipient of the University of Adelaide Endeavor International Postgraduate Research Scholarship, and Dr. Neil was a recipient of the Cardiovascular & Lipid Research grant (Australia).