Journal article
The potential impact of a hepatitis C vaccine for people who inject drugs: Is a vaccine needed in the age of direct-acting antivirals?
J Stone, NK Martin, M Hickman, M Hellard, N Scott, E McBryde, H Drummer, P Vickerman
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Background and Aims The advent of highly effective hepatitis C (HCV) treatments has questioned the need for a vaccine to control HCV amongst people who inject drugs (PWID). However, high treatment costs and ongoing reinfection risk suggest it could still play a role. We compared the impact of HCV vaccination amongst PWID against providing HCV treatment. Methods Dynamic HCV vaccination and treatment models among PWID were used to determine the vaccination and treatment rates required to reduce chronic HCV prevalence or incidence in the UK over 20 or 40 years. Projections considered a low (50% protection for 5 years), moderate (70% protection for 10 years) or high (90% protection for 20 years)..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
JS acknowledges funding from a PhD scholarship from the Engineering and Physical Sciences Research Council (EPSRC); MHi, PV and NKM acknowledge support from the National Institute for Health Research (NIHR) Health Protection Research Unit on Evaluation of Interventions; NKM acknowledges research funding from the National Institute for Drug Abuse (R01 DA037773-01A1) and the University of California San Diego Center for AIDS Research(CFAR), an NIH-funded program (P30 AI036214), which is supported by the following NIH Institutes and Centers: NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA, NIGMS, and NIDDK. NS is the recipient of a Burnet Institute Jim and Margaret Beever fellowship; EM, HD and MHe are the recipients of National Health and Medical Research Council fellowships. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health.