The neuronal noradrenaline transporter, anxiety and cardiovascular disease.
Murray Esler, Marlies Alvarenga, Ciaran Pier, Jeff Richards, Assam El-Osta, David Barton, Deepak Haikerwal, David Kaye, Markus Schlaich, Ling Guo, Garry Jennings, Flora Socratous, Gavin Lambert
J Psychopharmacol | Published : 2006
Panic disorder can serve as a clinical model for testing whether mental stress can cause heart disease. Potential neural mechanisms of cardiac risk are the sympathetic activation during panic attacks, continuing release of adrenaline as a co-transmitter in the cardiac sympathetic nerves, and impairment of noradrenaline neuronal reuptake, augmenting sympathetic neural respnses. The phenotype of impaired neuronal reuptake of noradrenaline: an epigenetic mechanism? We suspect that this phenotype, in sensitizing people to heart symptom development, is a cause of panic disorder, and by magnifying the sympathetic neural signal in the heart, underlies increased cardiac risk. No loss of function mut..View full abstract