Conference Proceedings

Human Sympathetic Nerve Biology Parallel Influences of Stress and Epigenetics in Essential Hypertension and Panic Disorder

Murray Esler, Nina Eikelis, Markus Schlaich, Gavin Lambert, Marlies Alvarenga, David Kaye, Assam El-Osta, Ling Guo, David Barton, Ciaran Pier, Celia Brenchley, Tye Dawood, Garry Jennings, Elisabeth Lambert, R Kvetnansky (ed.), G Aguilera (ed.), D Goldstein (ed.), D Jezova (ed.), O Krizanova (ed.), EL Sabban (ed.) Show all

Stress, Neurotransmitters, and Hormones: Neuroendocrine and Genetic Mechanisms | BLACKWELL PUBLISHING | Published : 2008


Patients with panic disorder provide a clinical model of stress. On a "good day," free from a panic attack, they show persistent stress-related changes in sympathetic nerve biology, including abnormal sympathetic nerve single-fiber firing ("salvos" of multiple firing within a cardiac cycle) and release of epinephrine as a cotransmitter. The coreleased epinephrine perhaps originates from in situ synthesis by phenylethanolamine N-methyltransferase (PNMT). In searching for biological evidence that essential hypertension is caused by mental stress--a disputed proposition--we note parallels with panic disorder, which provides an explicit clinical model of stress: (1) There is clinical comorbidity..

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University of Melbourne Researchers