Journal article
Altered Reward Reactivity as a Behavioural Endophenotype in Eating Disorders: A Pilot Investigation in Twins
N Kanakam, I Krug, D Collier, J Treasure
European Eating Disorders Review | WILEY | Published : 2017
DOI: 10.1002/erv.2512
Abstract
Altered reward reactivity is a potential risk endophenotype for eating disorders (EDs). The aim of this study was to examine reward reactivity in female twins with EDs and compare it with a twin control group. A sample of 112 twins [n = 51 met lifetime DSM-IV ED criteria (anorexia nervosa n = 26; bulimic disorders n = 24), n = 19 unaffected cotwins and n = 42 control twins] was administered measures assessing reward reactivity, including the Game of Dice Task, the Behavioural Inhibition/Activation (BIS/BAS) Scales and the Appetitive Motivation Scale (AMS). Within pair, correlations for monozygotic and dizygotic twins were calculated and generalised estimating equations compared probands with..
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Funding Acknowledgements
This research was in part funded by the Medical Research Council Scholarship awarded to Natalie Kanakam. The authors acknowledge training/support from the Institute of Psychiatry, King's College London. We would like to thank the Department of Twin Research and Genetic Epidemiology Kings College London for their help with recruiting the twins. Lastly, we are most grateful to all the twins, and thank them for their participation.