Journal article

An in vitro electrophysiological study of the colon from patients with idiopathic chronic constipation.

CH Hoyle, MA Kamm, JE Lennard-Jones, G Burnstock

Clinical Autonomic Research | Published : 1992


Preparations of the circular muscle layer from the sigmoid colon resected from patients with idiopathic chronic constipation were compared, at an electrophysiological level using the sucrose-gap technique, with preparations of the same region of the intestine resected from patients with rectal carcinoma. Non-adrenergic, non-cholinergic inhibitory neuromuscular transmission, represented by inhibitory junction potentials, was present in preparations from both groups. However, the inhibitory response in preparations from constipated patients had a slower or longer time-course than in those from cancer patients. Also, rebound activity following inhibitory transmission was observed in 34% of prep..

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