Journal article

PEPTIDE-CONTAINING NEURONS IN DIFFERENT REGIONS OF THE SUBMUCOUS PLEXUS OF HUMAN SIGMOID COLON

R CROWE, MA KAMM, G BURNSTOCK, JE LENNARDJONES

GASTROENTEROLOGY | W B SAUNDERS CO-ELSEVIER INC | Published : 1992

Abstract

Specimens of the sigmoid colon were obtained from male and female patients (n = 11) with carcinoma of the colon or rectum and studied immunohistochemically for vasoactive intestinal polypeptide-, somatostatin-, substance P-, neuropeptide Y-, calcitonin gene-related peptide-, met- and leu-enkephalin-, 5-hydroxytryptamine-, and dopamine beta-hydroxylase-containing nerves. In the subdivisions of the submucous plexus (namely, Schabadasch's, Meissner's, and the intermediate plexuses), substance P- and vasoactive intestinal polypeptide-immunoreactive nerve fibers were the most numerous, and equal densities of these nerves were found in all three layers. In contrast, few neuropeptide Y-, met-enkeph..

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