Hypoxia Stimulates Vesicular ATP Release From Rat Osteoblasts
Isabel R Orriss, Gillian E Knight, Jennifer C Utting, Sarah EB Taylor, Geoffrey Burnstock, Timothy R Arnett
Journal of Cellular Physiology | WILEY | Published : 2009
Many neuronal and non-neuronal cell types release ATP in a controlled manner. After release, extracellular ATP (or, following hydrolysis, ADP) acts on cells in a paracrine manner via P2 receptors. Extracellular nucleotides are now thought to play an important role in the regulation of bone cell function. ATP (and ADP), acting via the P2Y(1) receptor, stimulate osteoclast formation and activity, whilst P2Y(2) receptor stimulation by ATP (or UTP) inhibits bone mineralization by osteoblasts. We found that rat calvarial osteoblasts released ATP constitutively, in a differentiation-dependent manner, with mature, bone-forming osteoblasts releasing up to sevenfold more ATP than undifferentiated, pr..View full abstract
Awarded by Arthritis Research Campaign
Awarded by European Union
The authors gratefully acknowledge the support of the Arthritis Research Campaign grant numbers. They are: A0565, 17352 and the European Union Framework 7 programme (award no. 202231).