Journal article
The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma
C Keane, C Gould, K Jones, D Hamm, D Talaulikar, J Ellis, F Vari, S Birch, E Han, P Wood, KA Le-Cao, MR Green, P Crooks, S Jain, J Tobin, RJ Steptoe, MK Gandhi
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2017
Abstract
Purpose: To investigate the relationship between the intratumoral T-cell receptor (TCR) repertoire and the tumor microenvironment (TME) in de novo diffuse large B-cell lymphoma (DLBCL) and the impact of TCR on survival. Experimental Design: We performed high-throughput unbiased TCRβ sequencing on a population-based cohort of 92 patients with DLBCL treated with conventional (i.e., non-checkpoint blockade) frontline "R-CHOP" therapy. Key immune checkpoint genes within the TME were digitally quantified by nano-String. The primary endpoints were 4-year overall survival (OS) and progression-free survival (PFS). Results: The TCR repertoire within DLBCL nodes was abnormally narrow relative to non-d..
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Funding Acknowledgements
We acknowledge funding support from the Pathology Queensland Study, Education and Research Committee, the Leukaemia Foundation of Queensland, the Leukaemia Foundation of Australia - Bridgestone Award, Metro South Health Private Practice Trust Fund, and the Princess Alexandra Research Foundation.