Journal article

Efficacy of Hepatitis B Vaccine Against Antiviral Drug-Resistant Hepatitis B Virus Mutants in the Chimpanzee Model

Saleem Kamili, Vitini Sozzi, Geoff Thompson, Katie Campbell, Christopher M Walker, Stephen Locarnini, Krzysztof Krawczynski

HEPATOLOGY | WILEY | Published : 2009


UNLABELLED: Hepatitis B virus (HBV) mutants resistant to treatment with nucleoside or nucleotide analogs and those with the ability to escape from HBV-neutralizing antibody have the potential to infect HBV-vaccinated individuals. To address this potential serious public health challenge, we tested the efficacy of immunity induced by a commercial hepatitis B vaccine against a tissue culture-derived, clonal HBV polymerase mutant in HBV seronegative chimpanzees. The polymerase gene mutant contained a combination of three mutations (rtV173L, rtL180M, rtM204V), two of which resulted in changes to the overlapping viral envelope of the hepatitis B surface antigen (sE164D, sI195M). Prior to the HBV ..

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