Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations

Amanda L Aloia; Nicholas S Eyre; Stuart Black; Stephen J Bent; Adriana Gaeguta; Zhuyan Guo; Sumudu K Narayana; Robert Chase; Stephen Locarnini; Jill M Carr; John A Howe; Michael R Beard

Journal article

Generation of a chimeric hepatitis C replicon encoding a genotype-6a NS3 protease and assessment of boceprevir (SCH503034) sensitivity and drug-associated mutations

Amanda L Aloia, Nicholas S Eyre, Stuart Black, Stephen J Bent, Adriana Gaeguta, Zhuyan Guo, Sumudu K Narayana, Robert Chase, Stephen Locarnini, Jill M Carr, John A Howe, Michael R Beard

Antiviral Therapy | INT MEDICAL PRESS LTD | Published : 2015

DOI: 10.3851/IMP2850

University of Melbourne Researchers

Stephen Locarnini Author Microbiology and Immunology

Grants

Funding Acknowledgements

The authors are grateful to Julie Calvart (School of Medicine, Flinders University, Adelaide, Australia) for her expert technical assistance with this work. This work was supported in part by a research grant from the Investigator Initiated Studies Program of Merck Sharp and Dohme (Australia) Pty Ltd. The opinions expressed in this paper are those of the authors and do not necessarily represent those of Merck Sharp and Dohme (Australia) Pty Ltd. SL and MRB conceived the project. ALA designed and performed experiments, analysed data and wrote the manuscript. NSE, SB, SJB, AG, SKN, RC, SL, JMC and JAH analysed data and/or performed experiments. NSE, SB, AG, JMC, JAH and MRB contributed to the preparation of the manuscript.