Conference Proceedings

Subcortical Brain Alterations in Major Depressive Disorder: Findings from the ENIGMA Major Depressive Disorder Working Group

Lianne Schmaal, Dick J Veltman, Theo GM van Erp, Brenda WJH Penninx, Paul M Thompson, Derrek P Hibar

BIOLOGICAL PSYCHIATRY | ELSEVIER SCIENCE INC | Published : 2015

Abstract

Alterations in regional subcortical brain volumes have been widely investigated as part of the efforts of an international consortium, ENIGMA, to determine reliable structural brain signatures for Major Depressive Disorder (MDD). Given that subcortical structures are comprised of distinct subfields, we sought to build significantly from prior work to precisely map localized MDD-related differences in subcortical regions using shape analysis. In this meta-analysis of subcortical shape from the ENIGMA-MDD working group, we compared 1,781 patients with MDD and 2,953 healthy controls (CTL) on individual measures of shape metrics (thickness and surface area) on the surface of seven bilateral subc..

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